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The mean baseline ldl-c value was 225 mg dl range 161-351 mg dl in the zetia coadministered with simvastatin group compared to 219 mg dl range 149-336 mg dl in the simvastatin monotherapy group.
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No evidence of mutagenicity was observed in vitro in a microbial mutagenicityAmestest with Salmonella typhimurium and Escherichia coli with or without metabolic activationNo evidence of clastogenicity was observed in vitro in a chromosomal aberration assay in human peripheral blood lymphocytes with or without metabolic activationIn additionthere was no evidence of genotoxicity in the in vivo mouse micronucleus test.
There are no adequate and well-controlled studies of ezetimibe in pregnant womenEzetimibe should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the bloodEzetimibe may be used alone or with other drugssuch asstatinsor fibratesEzetimibe works by reducing the amount of cholesterol your body absorbs from your dietReducing cholesterol may help prevent strokes and heart attacks.
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initially it was a combination of zetia and zocor, but since both of those have gone generic, vytorin now contains ezetimibe and simvastatin.