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A minority of clozaril-treated patients experience ecg repolarization changes similar to those seen with other antipsychotic drugs, including s-t segment depression and flattening or inversion of t waves, which all normalize after discontinuation of clozaril.

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Rare but serious reports of seizuresincluding onset of seizures in non-epileptic patientsand isolated cases of delirium where Clozaril was co-administered with valproic acid have been reportedThese effects are possibly due to a pharmacodynamic interactionthe mechanism of which has not been determined.

Since Clozaril may be associated with thromboembolismimmobilisation of patients should be avoided.

This medication may rarely make your blood sugar risewhich can cause or worsen diabetesTell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urinationIf you already have diabetescheck your blood sugar regularly as directed and share the results with your doctorYour doctor may need to adjust your diabetes medicationexercise programor diet.

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