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Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscleOxybutynin chloride exhibits only one fifth of the anticholinergic activity of atropine on the rabbit detrusor musclebut four to ten times the antispasmodic activityNo blocking effects occur at skeletal neuromuscular junctions or autonomic gangliaantinicotinic effects
The mean pharmacokinetic parameters for Rand S-oxybutynin are summarized in Table 1The plasma concentration-time profiles for Rand S-oxybutynin are similar in shapeFigure 1 shows the profile for R-oxybutynin.
DITROPAN is also contraindicated in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.
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