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Because no information is available regarding the use of losartan during breastfeedinglosartan is not recommended and alternative treatments with better established safety profiles during breastfeeding are preferableespecially while nursing a newborn or preterm infant.
Losartan is not recommended in children with glomerular filtration rate 2 as no data are availablesee section 4.2
If symptomatic hypotension should occursupportive treatment should be instituted.
About 14of an intravenouslyor orally-administered dose of losartan is converted to its active metaboliteFollowing oral and intravenous administration of 14 C-labelled losartan potassiumcirculating plasma radioactivity primarily is attributed to losartan and its active metaboliteMinimal conversion of losartan to its active metabolite was seen in about one percent of individuals studied.
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