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Topical nonsteroidal anti-inflammatory drugs nsaids such as diclofenac voltaren and ketorolac acular are modestly useful in reducing pain from corneal abrasions.

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Based on the mechanism of actionthe use of prostaglandin-mediated NSAIDsincluding VOLTARENmay delay or prevent rupture of ovarian follicleswhich has been associated with reversible infertility in some womenPublished animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin-mediated follicular rupture required for ovulationSmall studies in women treated with NSAIDs have also shown a reversible delay in ovulationConsider withdrawal of NSAIDsincluding VOLTARENin women who have difficulties conceiving or who are undergoing investigation of infertility.

NSAIDs may diminish the antihypertensive effect of angiotensin converting enzymeACEinhibitorsangiotensin receptor blockersARBsor beta-blockersincluding propranololIn patients who are elderlyvolume-depletedincluding those on diuretic therapyor have renal impairmentco-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal functionincluding possible acute renal failureThese effects are usually reversible.

Ifat any time while taking Voltaren you experience any signs or symptoms of problems with your heart or blood vessels such as chest painshortness of breathweaknessor slurring of speechcontact your doctor immediatelyThese may be signs of cardiovascular toxicity.

Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto diclofenac or any components of the drug productsee WARNINGSAnaphylactic ReactionsSerious Skin ReactionsHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDs have been reported in such patientssee WARNINGSAnaphylactic ReactionExacerbation Of Asthma Related To Aspirin SensitivityIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGSCardiovascular Thrombotic Events

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