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AffiliationsSwiss Tropical and Public Health InstituteBaselSwitzerlandUniversity of BaselBaselSwitzerland.

This section provides information on the location and the topology of the mature protein in the cell.

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Abnormal alpha-1 antitrypsin proteins may bind together to buy toradol injection online form a large moleculeor polymerthat cannot leave the liverThe accumulation of these polymers results in liver damageIn additionlung tissue is destroyed because not enough alpha-1 antitrypsin is available to protect against neutrophil elastasePolymers of alpha-1 antitrypsin may also contribute to excessive inflammationwhich may explain some of the other features of alpha-1 antitrypsin deficiencysuch as a skin condition called panniculitis.

We present here an agnostic investigation of genetic determinants of circulating AAT levels in a general population sample by performing a genome-wide association studyGWASin 1392 individuals of the SAPALDIA cohort.

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