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The low plasma concentrations of known active and inactive metabolites of doxazosin retard 2-piperazinyl, 6 – and 7 -hydroxy and 6- and 7-o-desmethyl compounds compared to parent drug indicate that the contribution of even the most potent compound 6 -hydroxy to the antihypertensive effect of doxazosin retard in man is probably small.

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You should see a benefit from this drug within 1 to 2 weeksTell your doctor if your condition does not improve or if it worsensfor exampleyour blood pressure readings remain high or increaseor your BPH symptoms worsen

Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to purchase slimexotica benefit from more aggressive treatment to a lower blood pressure goal.

Intraoperative floppy iris syndrome reported in cataract surgery patients who received alph1-blocker therapydiscontinuing alpha-blocker therapy prior to surgery does not appear to be of benefit.

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