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Disposition of HMG-CoA reductase inhibitorsincluding rosuvastatininvolves OATP1B1 and other transporter proteinsHigher plasma concentrations of rosuvastatin have been reported in very small groups of patientsn=3 to 5who have two reduced function alleles of the gene that encodes OATP1B1SLCO1B1 521TCThe frequency of this genotypei.eSLCO1B1 521 C/Cis generally lower than 5in most racial/ethnic groupsThe impact of this polymorphism on efficacy and/or safety of rosuvastatin has not been clearly established.

CRESTOR reduces TotalCLDLCApoBnonHDLCand TGand increases HDLCin adult patients with hyperlipidemia and mixed dyslipidemia.

Rosuvastatin was not mutagenic or clastogenic with or without metabolic activation in the Ames test with Salmonella typhimurium and Escherichia colithe mouse lymphoma assayand the chromosomal aberration assay in Chinese hamster lung cellsRosuvastatin was negative in the in vivo mouse micronucleus test.

CRESTOR should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver cheap tadalista online pharmacy diseasesee CLINICAL PHARMACOLOGYActive liver diseasewhich may include unexplained persistent transaminase elevationsis a contraindication to the use of CRESTORsee CONTRAINDICATIONS

Public Citizen demanded the FDA recall the drug before any further incidents of rhabdomyolysiskidney failure or kidney damage could occur.

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